Cinnamtannin A2, (−)-epicatechin tetramer, attenuates skeletal muscle wasting in disuse atrophy model mice induced by hindlimb suspension

The impact of repeated administration cinntamtannin A2 (A2, 25 μg/kg) on skeletal muscle disuse atrophy model mice induced by hindlimb suspension for 14 days was examined. In soleus, weight loss and a reduction in the average myofibre size with shifting to smaller side peak were observed suspension-vehicle group, but reduced these changes. Average significantly increased ground-A2 compared ground-vehicle. A marked increase dephosphorylation forkhead box O (FoxO) 3a A2. phosphorylation Akt eukaryotic translation initiation factor 4E-binding protein (4EBP)-1 treatment addition, single dose dramatically 24-h excretion catecholamines urine. These results suggest that sympa­thetic nerve activation promotes hypertrophy while inhibiting progress atrophy.